EFFECTS OF CATHOLYTE WATER ON THE DEVELOPMENT OF EXPERIMENTAL GRAFFI TUMOR ON HAMSTERS

Reneta Toshkova, Elissaveta Zvetkova, Ignat Ignatov, Georgi Gluhchev

Abstract


Validity. The paper describes the results of a study aimed at the investigation of the influence of electrolyzed alkaline water (catholyte) on the tumor development in hamsters. At present there are no much data about the effect of catholyte on the tumor growth and hematological parameters of experimental animals.
Goal: The goal of the present work is to investigate biological effects of the catholyte on the tumor growth , hematological biomarkers and morphology of the blood cells from tumor-bearing hamsters.
Methods: Graffi tumor was transplanted subcutaneously in the back of the experimental group of Golden Syrian hamsters. Tumor appearance and growth were registered every day. Blood parameters were measured from blood smears on the 10th and 25th day after transplantation.
Results: Hamsters treated with catholyte developed tumor with some delay. Also, the tumor growth was slow and the survival rate was increased. The analysis of blood parameters and cell morphology has shown significant differences in the value of some hematometric parameters and morphological changes of some blood cells.
Conclusion: The obtained results suggest about the beneficial influence of catholyte as well as the possible use of it as a supporting non-invasive therapy of cancer diseases.
Keywords: Graffi tumor, catholyte, tumor growth, survival rate, mortality, blood parameters.

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