Studies were conducted with model systems of bio influence (Drossinakis’ method) with electromagnetic (e.m.) fields and infrared thermal field (ITF) (Ignatov et al., 2013). The purpose of research is to analyze effects over DNA. Analysis of effects over water and physiological saline is carried out in the report. Results are achieved with blood serum of hamsters and physiological processes in hamsters with tumors. The water analyses have been conducted with Nonequilibrium Energy Spectrum (NES) and Differential Nonequilibrium Energy Spectrum (DNES) methods (Antonov, 1992; Ignatov, 1998). Experiments were carried out about the influence on tumor cells of mice in water. Reduction of DNES spectrum according to the control sample of cells in healthy animals was observed. (Antonov, 1992). Reduction is also observed in DNES spectrum in blood serum of people having oncological diseases, compared to the one of healthy people (Ignatov, 2012). Such a reduction is most prevalent in (-0.1387 eV; 8.95 µm; 1117 cm-1). In research of the effects of e.m. fields in water and blood serum from hamsters the range is (-0.08 – -0.14 eV) (8.9 – 15.5µm) (645–1129 cm-1). Research is conducted for the effects over Graffi tumor that was implanted in hamsters (Toshkova et al., 2019). Studies are conducted with pH and oxidation redox potential (ORP) effects of e.m. fields over physiological saline (Gluhchev et al., 2019). Keywords: Infrared thermal field (ITF), electromagnetic fields (e.m. fields), experimental Graffi solid tumor, energy spectrum, NES and DNES methods.